Journal: medRxiv

Article Title: Stricker Learning Span criterion validity: a remote self-administered multi-device compatible digital word list memory measure shows similar ability to differentiate amyloid and tau PET-defined biomarker groups as in-person Auditory Verbal Learning Test

doi: 10.1101/2022.10.26.22281534

Figure Lengend Snippet: Stricker Learning Span (SLS, left panel) and Auditory Verbal Learning Test (AVLT, right panel) learning slopes and delayed memory performances across all participants without AD biomarkers (A-T-, blue) and all participants with biological AD (A+T+, red). Note . Sum of trials is the primary variable for each test; these figures show the data comprising sum of trials for each measure (sum of trials = total correct items for all trials displayed in each respective figure). SLS items presented differ by trial based on computer adaptive testing rules, thus the highest possible number of presented across trials vary (see for ceiling and floor values for Trials 1-5; the delay trial can range from 8-23). The SLS uses 4-choice recognition to test item memory. In contrast, 15 words are presented each time for AVLT trials (constant range of 0-15) and item memory is tested with free recall. See Supplemental Table 2 for numeric results. AVLT Trial 6 = short-delay. AVLT delay = 30-minute delay. Figure used with permission of Mayo Foundation for Medical Education and Research; all rights reserved.

Article Snippet: In contrast, our prior work examining the utility of the Learning/Working Memory index comprised of visual recognition and working memory tasks from the Cogstate Brief Battery administered in clinic did not significantly differentiate biomarker groups better than chance (CU A-T- vs CU A+T+ or CU A- T- vs CU A+T-) and showed that the AVLT was significantly better than the Learning/Working Memory Index for differentiating CU A-T- vs CU A+T- when comparing total AUROCs.

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